PIXER Single-Use
Bioprocessing Pump

PIXER's five-diaphragm Polymorphic configuration phases displacement cycles at 72° intervals versus 90° for traditional quaternary pumps. This tighter phasing creates significantly smoother flow with lower pressure pulsation.

Performance impact: Reduced pulsation protects TFF membranes from fatigue, improves process control stability, and minimizes mechanical stress on sensitive biologics. The radial arrangement also delivers 50% smaller footprint compared to linear quaternary configurations while maintaining equivalent flow rates.

The vertical design with gravity-flooded top inlet eliminates three common failure modes: cavitation at the inlet, air entrapment during priming, and incomplete draining after processing.

Instant priming without manual purging. Air naturally rises and exits through the outlet. The bottom-positioned outlet enables complete product recovery—critical when processing high-value biologics where even 100mL of trapped material represents significant loss.

PIXER's optimized displacement geometry per diaphragm generates greater volumetric output per revolution. The five-diaphragm radial configuration delivers equivalent flow rates to quaternary competitors while running at dramatically lower motor speeds.

Lower RPM means less mechanical wear, reduced vibration, and extended service life. It also reduces heat generation and power consumption—particularly relevant for continuous bioprocessing operations running 24/7.

Traditional diaphragm pumps experience significant flow degradation under backpressure due to check valve inefficiency and diaphragm deflection limitations. PIXER's engineered check valve geometry and optimized diaphragm mechanics maintain volumetric displacement even at 4 bar.

Real-world impact: When driving TFF systems, depth filters, or chromatography columns that create substantial backpressure, PIXER maintains target flow rates without requiring oversized pump models or frequent speed adjustments.

The diaphragm forms a complete physical barrier between the drive mechanism and process fluid. Process media never contacts moving mechanical components. No impellers, no compression zones, no turbulent eddies.

Validated with IgG, RBCs, and CHO cells through extended recirculation testing showing zero statistically significant cell damage. Critical for viral vectors, mRNA-LNPs, and cell therapies where mechanical stress causes titer loss or reduces therapeutic efficacy.

PIXER's radial diaphragm arrangement minimizes internal fluid path length between inlet and outlets. Combined with vertical orientation and bottom outlet positioning, the pump enables gravity-assisted draining rather than relying on subsequent fluid to push product through.

For a 10L batch, competitor pumps with 500mL+ hold-up lose 5% of product. PIXER's minimized hold-up (22mL to 2150mL depending on scale) maximizes yield—directly impacting batch economics for high-value biologics.

All PIXER wetted components meet FDA 21 CFR compliance and USP Class VI biocompatibility. Materials include polypropylene body discs, Novelast® TPV diaphragms/check valves, and EPDM O-rings—all BSE/TSE free with documented extractables and leachables profiles.

Manufacturing: ISO Class 7 cleanroom production with gamma irradiation sterilization validation. Complete Design History Files and Device Master Records support customer regulatory submissions per 21 CFR Part 820.

Eliminates cleaning validation, CIP/SIP cycles, and cross-contamination risk. Changeover requires only installing a new pump head—no multi-day cleaning procedures or validation studies between campaigns.

Economic benefits: Removes water consumption, chemical waste, and sterilization energy costs. For multi-product facilities, PIXER enables rapid campaign changes without revalidation. Particularly valuable in cell & gene therapy where batch sizes are small but product values justify single-use economics.

PIXER P0 through P40 models (0.45 L/min to 200 L/min) use identical five-diaphragm radial configuration and vertical orientation across the full range. Process parameters validated at pilot scale translate directly to production without modifying pump speed, pressure setpoints, or control strategies.

No technology switching penalty. Switching from peristaltic to diaphragm, or quaternary to different quaternary during scale-up introduces new flow behavior requiring revalidation. PIXER's consistent architecture reduces tech transfer complexity and regulatory burden.

Pump pulsation creates oscillating transmembrane pressure that accelerates membrane fouling and reduces permeate flux consistency. Pressure oscillations cause compression/relaxation cycles that compact the fouling layer and shorten membrane lifetime.

PIXER's five-diaphragm phasing at 72° intervals (versus 90° for quaternary pumps) delivers significantly smoother flow. This maintains stable TMP, extends membrane life, and enables tighter process control—critical for perfusion and continuous bioprocessing where consistent performance over days to weeks is essential.